国产三级在线,99免费精品视频,日韩精品人妻中文字幕有码无码,午夜福利视频无码一区二区三区

測量應(yīng)用案例-20210409

文獻名：Nanoemulsion for improving the oral bioavailability of hesperetin: formulation optimization and absorption mechanism

作者：Fanyu Zeng^a; Dandan Wang^a; Yan Tian^a; Min Wang^a; Rui Liu^a; Zhining Xia^a; Yike Huang^b

^a School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China

^b College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China

摘要：This study aimed to prepare a nanoemulsion vehicle to improve the oral bioavailability of hesperetin. The pseudo-ternary phase diagrams and the RSM were used to optimize nanoemulsion parameters. Compared with hesperetin suspension, the AUC_0-t and C_max of nanoemulsion were increased by 5.67-fold and 2.64-fold, respectively. The proportion of lymphatic transport reached 87.72%, the cumulative absorption amount of jejunum, ileum, and duodenum increased by 1.1-fold, 1.92-fold, and 1.5-fold, respectively. The results implied that hesperetin nanoemulsion could effectively improve the bioavailability of hesperetin by increasing lymphatic transport and enhancing intestinal permeability. Therefore, nanoemulsion is a potential method to improve the bioavailability of hesperetin, which has strong practicability.

關(guān)鍵詞：Nanodrug; Intestinal absorption; Hesperetin; Bioavailability; Pharmacokinetics